当前位置: X-MOL 学术Nat. Rev. Neurosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
Nature Reviews Neuroscience ( IF 34.7 ) Pub Date : 2017-11-09 , DOI: 10.1038/nrn.2017.128
Ileana Micu , Jason R. Plemel , Andrew V. Caprariello , Klaus-Armin Nave , Peter K. Stys

It is widely recognized that myelination of axons greatly enhances the speed of signal transmission. An exciting new finding is the dynamic communication between axons and their myelin-forming oligodendrocytes, including activity-dependent signalling from axon to myelin. The oligodendrocyte–myelin complex may in turn respond by providing metabolic support or alter subtle myelin properties to modulate action potential propagation. In this Opinion, we discuss what is known regarding the molecular physiology of this novel, synapse-like communication and speculate on potential roles in disease states including multiple sclerosis, schizophrenia and Alzheimer disease. An emerging appreciation of the contribution of white-matter perturbations to neurological dysfunction identifies the axo-myelinic synapse as a potential novel therapeutic target.



中文翻译:

轴索-回肠神经传递:中枢神经系统中细胞信号传导的一种新模式。

众所周知,轴突的髓鞘化大大提高了信号传输的速度。激动人心的新发现是轴突与其形成髓磷脂的少突胶质细胞之间的动态交流,包括从轴突到髓磷脂的活性依赖性信号传导。少突胶质细胞-髓鞘复合物可能反过来通过提供代谢支持或改变微妙的髓鞘特性来调节动作电位的传播而作出反应。在这份意见书中,我们讨论了有关这种新颖的,类似于突触的交流的分子生理学,并推测了在疾病状态(包括多发性硬化症,精神分裂症和阿尔茨海默氏病)中的潜在作用。对白质摄动对神经功能障碍的贡献的一种新的认识认为,轴突-髓鞘突触是潜在的新型治疗靶标。

更新日期:2017-11-10
down
wechat
bug