Theranostics that combines the disease diagnosis with treatment is of promising application in the foreground of personalized medicine to achieve a precise treatment with minimum side effects. In this work, we strategically designed a “four-in-one” theranostic nanoplatform for realizing the desired imaging-guided phototherapy, in which functions of fluorescent imaging, photoacoustic imaging tomography (PAT), photothermal therapy (PTT) and photodynamic therapy (PDT) were implemented by bioconjugated MoS₂ nanosheets. The protagonist of MoS₂ is a light-harvesting material in the near-infrared (NIR) region, which would produce localized hyperthermia at the tumor site to trigger the photothermal therapy effect for the tumor ablation as well as a PAT signal to depict the tumor concurrently upon NIR excitation. To our surprise, MoS₂ has been found to be a photosensitizer for the cancer PDT treatment as well. Moreover, bovine serum albumin (BSA) decoration on MoS₂ has been made to improve biocompatibility, which also allowed further conjugation with a fluorescent molecule of Cy5.5 to endow the overall nanoplatform with fluorescence imaging and monitoring features. On the basis of the above characters, great successes in cancer imaging and tumor photoablation were achieved in both in vitro and in vivo experiments. Innovatively, B-ultrasonography and MRI imaging were employed to monitor the elimination process of solid tumor after treatment, which clearly revealed a liquefaction necrosis process for rehabilitation. In short, MoS₂ represents a nanoplatform of this work and manifested huge advantages in the cancer theranostics.

中文翻译：

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基于MoS ₂的多功能治疗学纳米平台：实现双成像引导组合光疗，通过液化坏死过程消除实体瘤

结合疾病诊断和治疗的治疗诊断学在个性化医学的前景中有望实现具有最小副作用的精确治疗。在这项工作中，我们策略性地设计了一种“四合一”治疗神经病纳米平台，以实现所需的成像引导光疗，其中荧光成像，光声层析成像（PAT），光热疗法（PTT）和光动力疗法（PDT）的功能）是通过生物共轭MoS ₂纳米片实现的。MoS ₂的主角是在近红外（NIR）区域中的一种光收集材料，它将在肿瘤部位产生局部热疗，从而触发对肿瘤消融的光热治疗效果，以及PAT信号在NIR激发时同时描绘肿瘤。令我们惊讶的是，MoS ₂也被发现是用于癌症PDT治疗的光敏剂。此外，已经在MoS ₂上修饰牛血清白蛋白（BSA）以改善生物相容性，这还允许与Cy5.5荧光分子进一步缀合，使整个纳米平台具有荧光成像和监视功能。基于上述特征，在体外和体外均取得了成功的癌症成像和肿瘤光消融方面的成功。体内实验。创新地采用B超和MRI成像监测治疗后实体瘤的清除过程，清楚地揭示了液化坏死的修复过程。简而言之，MoS ₂代表了这项工作的纳米平台，并在癌症治疗学中显示出巨大的优势。