Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H,Organic Chemistry Frontiers

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Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1039/c7qo00934h
Jie Sheng _{1,

2,

3,

4} , Hui-Qi Ni _{1,

2,

3,

4} , Kang-Jie Bian _{1,

2,

3,

4} , Yan Li _{1,

2,

3,

4} , Yi-Ning Wang _{1,

2,

3,

4} , Xi-Sheng Wang _{1,

2,

3,

4}

Affiliation

A nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed for the first time, demonstrating good efficiency, mild conditions, and good functional-group compatibility. The key to success is the combination of different kinds of readily available nitrogen and phosphine ligands with a nickel source, which can generate a variety of easily tunable catalysts in situ to promote the difluoromethylation of a broad scope of aryl boronic acids.

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