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Microwave assisted domino heck cyclization and alkynylation: synthesis of alkyne substituted dihydrobenzofurans
Green Chemistry ( IF 9.8 ) Pub Date : 2017-10-27 00:00:00 , DOI: 10.1039/c7gc02606d
Ramesh Karu 1, 2, 3, 4 , Satyanarayana Gedu 1, 2, 3, 4
Affiliation  

Microwave assisted domino intramolecular Heck and Sonogashira coupling for the efficient synthesis of alkyne substituted dihydrobenzofurans is presented. Interestingly, the strategy showed broad substrate scope and was successful with protecting group free functionalities of acetylenes. Gratifyingly, all products were obtained, in excellent to near quantitative yields, in a short span of time.

中文翻译:

微波辅助的多米诺骨牌环化和炔基化:炔烃取代的二氢苯并呋喃的合成

微波辅助多米诺骨牌分子内Heck和Sonogashira耦合提出了炔烃取代的二氢苯并呋喃的有效合成。有趣的是,该策略显示了广泛的底物范围,并成功地保护了乙炔的无基团官能团。令人欣慰的是,所有产品都在短时间内以极佳的定量收率获得。
更新日期:2017-11-09
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