An efficient methodology is developed for the synthesis of functionalized specific carbazole lactams related to pyrido[4,3-b]- and quino[4,3-b] carbazole alkaloids. 3 C–C bonds and 2 rings are created in a single step via an indole-to-carbazole transformation triggered by Pd(II)-catalyzed direct C-3 alkenylation of indoles. Starting from a key pentacyclic precursor delivered by the methodology, calothrixin B is synthesized in 6 steps.

中文翻译：

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一种特定的喹[4,3- b ]咔唑啉酮体系的快速构建及其在合成calothrixin B中的应用

开发了一种有效的方法，用于合成与吡啶并[4,3- b ]-和喹[4,3- b ]咔唑生物碱相关的功能化特定咔唑内酰胺。3 C-C键和2个环是在单个步骤中创建经由通过将Pd（触发的吲哚向咔唑转化II）催化的吲哚的直接C-3烯基。从通过该方法提供的关键五环前体开始，Calothrixin B分6个步骤合成。