A cobalt-catalyzed C(sp²)–H/C(sp³)–H coupling reaction between an aryl imine and a 2-bromobenzyl-protected secondary amine is reported. Promoted by a combination of a cobalt–N-heterocyclic carbene catalyst and a Grignard reagent, the reaction allows for the introduction of α-aminoalkyl groups into the ortho position of the imine at a mild temperature. The cobalt catalyst is proposed to play key roles in two distinct modes of C–H cleavage, i.e., directed C–H metalation and 1,5-hydrogen atom transfer (HAT).

中文翻译：

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通过定向的C–H活化和1,5-氢原子转移，钴催化的C（sp ²）–H / C（sp ³）–H偶联

据报道，芳基亚胺和2-溴苄基保护的仲胺之间存在钴催化的C（sp ²）–H / C（sp ³）–H偶联反应。通过钴-N-杂环卡宾催化剂和格氏试剂的组合促进，该反应允许在温和的温度下将α-氨基烷基引入亚胺的邻位。提出钴催化剂在CH裂解的两种不同模式中起关键作用，即，定向CH金属化和1,5-氢原子转移（HAT）。