Metabolism is a key regulator of cancer biology; however, its role in therapeutic resistance has remained largely unresolved. Several new studies disclose that mitochondrial metabolism and oxidative phosphorylation at least in part drive chemoresistance in cancer and thus have important implications for targeted and more effective chemotherapies.

中文翻译：

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抵抗是徒劳的：靶向线粒体能量和代谢以克服癌症治疗中的耐药性。

代谢是癌症生物学的关键调节因子。然而，其在治疗抗性中的作用仍未得到解决。几项新的研究表明，线粒体的代谢和氧化磷酸化至少部分地驱动癌症的化学抗性，因此对靶向和更有效的化学疗法具有重要意义。