当前位置: X-MOL 学术Cell Metab. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Glial Cell Evolution: The Origins of a Lipid Store.
Cell Metabolism ( IF 29.0 ) Pub Date : 2017-Nov-07 , DOI: 10.1016/j.cmet.2017.10.011
Klaus-Armin Nave , Iva D. Tzvetanova , Stefanie Schirmeier

In Drosophila, neuronal mitochondria that lack OXPHOS generate ROS-protective fatty acids and lipid droplets in associated glia. In this issue, Liu et al. (2017) demonstrate that neuronal lipid synthesis is driven by the glial lactate shuttle. This lipoprotein-dependent deposition of lipids may be at the origin of glial specializations evolving in vertebrates.

中文翻译:

胶质细胞进化:脂质储存的起源。

在果蝇中,缺乏OXPHOS的神经元线粒体会在相关的神经胶质中产生ROS保护性脂肪酸和脂滴。在这个问题上,刘等。(2017)证明神经元脂质合成是由神经胶质乳酸穿梭驱动的。这种依赖脂蛋白的脂质沉积可能是脊椎动物中神经胶质专长的起源。
更新日期:2017-11-07
down
wechat
bug