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Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
Nature Structural & Molecular Biology ( IF 16.8 ) Pub Date : 2017-11-06 , DOI: 10.1038/nsmb.3502
Xiaoyuan Zhou , Minghui Li , Deyuan Su , Qi Jia , Huan Li , Xueming Li , Jian Yang

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states, Published online: 06 November 2017; doi:10.1038/nsmb.3502

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Cryo-EM analyses of human TRPML3 reveal this channel in three different states—closed, agonist-activated and low-pH-inhibited—and suggest mechanisms for regulation.

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中文翻译:

人溶酶体TRPML3通道的低温EM结构处于三种不同状态

人溶酶体TRPML3通道的低温EM结构处于三种不同状态

人内溶酶体TRPML3通道的低温EM结构在三个不同的状态,在线发布:2017年11月6日; doi:10.1038 / nsmb.3502

NatureArticleSnippet(type = short-summary,markup =

对人类TRPML3的冷冻EM分析揭示了该通道处于三种不同状态-封闭,激动剂激活和低pH抑制-并提出了调节机制。

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更新日期:2017-11-06
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