Inflammasome sensors recognize pathogens and danger signals and assemble an immune signaling complex, which induces the secretion of pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis. A new study published in Nature now describes a new inflammasome sensor NLRP9b in intestinal epithelial cells, which in concert with the RNA sensor DHX9, recognize short dsRNA from Rotavirus.

中文翻译：

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NLRP9b：一种新型的RNA感应炎症小体复合物

炎症小体传感器识别病原体和危险信号并组装免疫信号复合物，该复合物诱导促炎性细胞因子IL-1β和IL-18的分泌，并引起细胞凋亡。《自然》杂志上发表的一项新研究现在描述了一种在肠道上皮细胞中的新型炎性体传感器NLRP9b，该传感器与RNA传感器DHX9共同识别轮状病毒中的短dsRNA。