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Solvent‐free, l‐Leucine‐Catalyzed Direct Dehydrative Esterification of Carboxylic Acids with Alcohols: Direct Synthesis of 3‐Alkoxy 1(3 H)‐isobenzofuranone
Asian Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2017-12-05 , DOI: 10.1002/ajoc.201700523
Manoranjan Kumar 1, 2 , Krishna Thakur 1 , Sushila Sharma 1, 2 , Onkar S. Nayal 1, 2 , Neeraj Kumar 1 , Bikram Singh 1, 2 , Upendra Sharma 1, 2
Affiliation  

A l‐leucine‐catalyzed mild and efficient method has been developed for the synthesis of open‐chain as well as cyclic esters. A wide range of alcohols, including primary, secondary, and tertiary with aliphatic and aromatic side chains, were successfully tolerated. In the case of 2‐carboxybenzaldehydes with different alcohols, 3‐alkoxy‐1‐(3 H)‐isobenzofuranones were obtained in good yields. Alcohols from natural origin have also been reacted with various acids successfully to get the corresponding esters. The reaction proceeded under neat conditions and there is no need for any acid, base, or removal of water during the reaction.

中文翻译:

无溶剂,左旋亮氨酸催化的羧酸与醇的直接脱水酯化反应:3-烷氧基1(3 H)-异苯并呋喃酮的直接合成

已经开发了一种l-亮氨酸催化的温和高效的方法,用于合成开链酯和环状酯。成功地耐受了多种醇,包括带有脂肪族和芳香族侧链的伯,仲和叔醇。在使用不同醇的2-羧基苯甲醛的情况下,可以得到高收率的3-烷氧基-1-(3  H)-异苯并呋喃酮。天然来源的醇也已与各种酸成功反应,得到相应的酯。反应在纯净的条件下进行,并且在反应过程中不需要任何酸,碱或水的去除。
更新日期:2017-12-05
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