A direct route to chiral pyrimidine acyclic nucleoside analogues with a sulfur‐containing side chain is reported via enantioselective tandem conjugated addition‐protonation reactions of thioacetic acid to α‐pyrimidine substituted acrylates. In the presence of a quinine‐derived thiourea catalyst, diverse chiral sulfur‐containing pyrimidine acyclic nucleoside analogues could be obtained in excellent yields (95–99 %) and with moderate to excellent enantioselectivity values (up to 99 % ee).

中文翻译：

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通过对映选择性串联共轭加成/质子合成具有含硫侧链的手性无环嘧啶核苷。

据报道，通过硫代乙酸与α-嘧啶取代的丙烯酸酯的对映选择性串联共轭加质子化反应，可以直接制得具有含硫侧链的手性嘧啶无环核苷类似物。在存在奎宁衍生的硫脲催化剂的情况下，可以获得多种手性含硫嘧啶无环核苷类似物，收率极高（95-99％），对映选择性值中等至极好（ee高达99％）。