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Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure
Gut ( IF 24.5 ) Pub Date : 2017-09-19 , DOI: 10.1136/gutjnl-2017-314641 Tianzhou Wu , Jiang Li , Li Shao , Jiaojiao Xin , Longyan Jiang , Qian Zhou , Dongyan Shi , Jing Jiang , Suwan Sun , Linfeng Jin , Ping Ye , Lingling Yang , Yinyun Lu , Tan Li , Jianrong Huang , Xiaowei Xu , Jiajia Chen , Shaorui Hao , Yuemei Chen , Shaojie Xin , Zhiliang Gao , Zhongping Duan , Tao Han , Yuming Wang , Jianhe Gan , Tingting Feng , Chen Pan , Yongping Chen , Hai Li , Yan Huang , Qing Xie , Shumei Lin , Lanjuan Li , Jun Li
Gut ( IF 24.5 ) Pub Date : 2017-09-19 , DOI: 10.1136/gutjnl-2017-314641 Tianzhou Wu , Jiang Li , Li Shao , Jiaojiao Xin , Longyan Jiang , Qian Zhou , Dongyan Shi , Jing Jiang , Suwan Sun , Linfeng Jin , Ping Ye , Lingling Yang , Yinyun Lu , Tan Li , Jianrong Huang , Xiaowei Xu , Jiajia Chen , Shaorui Hao , Yuemei Chen , Shaojie Xin , Zhiliang Gao , Zhongping Duan , Tao Han , Yuming Wang , Jianhe Gan , Tingting Feng , Chen Pan , Yongping Chen , Hai Li , Yan Huang , Qing Xie , Shumei Lin , Lanjuan Li , Jun Li
Objective The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis, irrespective of aetiology, remains controversial. This study aimed to clarify the clinicopathological characteristics of patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective study and develop new diagnostic criteria and a prognostic score for such patients. Design The clinical data from 1322 hospitalised patients with acute decompensation of cirrhosis or severe liver injury due to chronic hepatitis B (CHB) at 13 liver centres in China were used to develop new diagnostic and prognostic criteria. Results Of the patients assessed using the Chronic Liver Failure Consortium criteria with the exception of cirrhosis, 391 patients with ACLF were identified: 92 with non-cirrhotic HBV-ACLF, 271 with cirrhotic HBV-ACLF and 28 with ACLF with cirrhosis caused by non-HBV aetiologies (non-HBV-ACLF). The short-term (28/90 days) mortality of the patients with HBV-ACLF were significantly higher than those of the patients with non-HBV-ACLF. Total bilirubin (TB) ≥12 mg/dL and an international normalised ratio (INR) ≥1.5 was proposed as an additional diagnostic indicator of HBV-ACLF, and 19.3% of patients with an HBV aetiology were additionally diagnosed with ACLF. The new prognostic score (0.741×INR+0.523×HBV-SOFA+0.026×age+0.003×TB) for short-term mortality was superior to five other scores based on both discovery and external validation studies. Conclusions Regardless of the presence of cirrhosis, patients with CHB, TB ≥12 mg/dL and INR ≥1.5 should be diagnosed with ACLF. The new criteria diagnosed nearly 20% more patients with an HBV aetiology with ACLF, thus increasing their opportunity to receive timely intensive management.
更新日期：2017-09-19
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