Cancer Discovery ( IF 28.2 ) Pub Date : 2017-11-01 , DOI: 10.1158/2159-8290.cd-17-0976 Rizwan Haq
Summary: The evolution of cancer cells limits the efficacy of nearly all treatments for patients with solid tumors. Characterizing how cancers adapt to treatment could therefore lead to approaches that overcome resistance to therapy. In this issue of Cancer Discovery, Song and colleagues describe the evolution of melanomas upon exposure to BRAF inhibitors, demonstrating that adaptive changes in the tumor create a vulnerability that can be targeted with immune checkpoint inhibitors. Cancer Discov; 7(11); 1216–7. ©2017 AACR.
See related article by Song et al., p. 1248.
中文翻译:
捕捉癌症以适应生存
简介:癌细胞的进化限制了几乎所有治疗实体瘤患者的疗效。因此,表征癌症如何适应治疗可能会导致克服对治疗的抵抗力的方法。在本期《癌症发现》中,Song及其同事描述了暴露于BRAF抑制剂后黑色素瘤的演变,证明了肿瘤中的适应性变化产生了可以被免疫检查点抑制剂靶向的脆弱性。巨蟹座Discov; 7(11);1216–7。©2017 AACR。
参见Song等人的相关文章,第1页。1248。