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At Last: Gene Editing in Human Embryos to Understand Human Development.
Cell Stem Cell ( IF 23.9 ) Pub Date : 2017-Nov-02 , DOI: 10.1016/j.stem.2017.10.008
Albert Ruzo , Ali H. Brivanlou

Our understanding of early human development is typically based on inference from animal models, which may not fully recapitulate human embryonic features. As proof of concept, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from its function in model systems.

中文翻译:

最后:人类胚胎中的基因编辑,以了解人类发展。

我们对人类早期发育的理解通常基于动物模型的推论,这可能无法完全概括人类的胚胎特征。作为概念的证明,Fogarty等人。(2017)使用CRISPR / Cas9基因消融了人类植入前胚胎中的OCT4基因,发现其在模型系统中的功能存在关键差异。
更新日期:2017-11-02
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