Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated late onset neurodegeneration driven by activated microglia.

中文翻译：

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强调突变的小胶质细胞：脑哨兵失调诱导神经退行性变。

反应性小胶质细胞通常与神经退行性疾病的病理有关。在《自然》杂志的最新研究中，Mass等人 （2017）证明早期红细胞-髓样前体（EMPs）中Braf的定向突变导致由激活的小胶质细胞驱动的组织细胞病相关的迟发性神经退行性变。