Tuberculosis is one of the most common and challenging infectious diseases worldwide. Especially, the lack of effective chemotherapeutic drugs for tuberculosis/human immunodeficiency virus co-infection and prevalence of multidrug-resistant and extensively drug-resistant tuberculosis remain to be serious clinical problems. Development of new drugs is a potential solution to fight tuberculosis. In this decade, the development status of new antituberculous drugs has been greatly advanced by the leading role of international organizations such as the Global Alliance for Tuberculosis Drug Development, Stop Tuberculosis Partnership and Global Health Innovative Technology Fund. In this review, we introduce the development status of new drugs for tuberculosis, focusing on those derived from natural products.The Journal of Antibiotics advance online publication, 1 November 2017; doi:10.1038/ja.2017.126.

中文翻译：

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天然产物衍生的新抗结核药物：抗结核药物开发的当前观点和问题。

结核病是全世界最常见和最具挑战性的传染病之一。尤其是，缺乏用于结核/人免疫缺陷病毒共感染的有效化学治疗药物以及多药耐药和广泛耐药的结核病的流行仍然是严重的临床问题。开发新药是抗击结核病的潜在解决方案。在这十年中，国际结核病药物开发联盟，制止结核病伙伴关系和全球卫生创新技术基金等国际组织的领导作用大大提高了抗结核新药的开发状况。在这篇综述中，我们介绍了结核病新药的开发现状，重点介绍了天然产物。《抗生素杂志》提前在线发布，2017年11月1日; doi：10.1038 / ja.2017.126。