At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to understand how these compartments are structurally registered and functionally integrated with one another. This review will describe the organization of each compartment and then discuss their alignment across pre- and postsynaptic cells at a nanometer scale. We propose that this architecture may allow for precise synaptic information exchange and may be modulated to contribute to the remarkable plasticity of brain function.

中文翻译：

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突触功能的跨细胞纳米排列。

在大脑的大量突触中，突触前神经末梢，突触裂隙和突触后特化形成跨细胞单元，以实现神经元之间信息的有效传递。虽然我们对每个隔室中的分子机制了解很多，但我们才刚刚开始了解这些隔室如何在结构上对齐并在功能上相互集成。这篇综述将描述每个小室的组织，然后讨论它们在突触前和突触后细胞之间的纳米级排列。我们建议这种体系结构可以允许精确的突触信息交换，并可以进行调制，以促进大脑功能的显着可塑性。