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Current Concepts in 68Ga-DOTATATE Imaging of Neuroendocrine Neoplasms: Interpretation, Biodistribution, Dosimetry, and Molecular Strategies
The Journal of Nuclear Medicine ( IF 9.3 ) Pub Date : 2017-11-01 , DOI: 10.2967/jnumed.116.186361
Lisa Bodei , Valentina Ambrosini , Ken Herrmann , Irvin Modlin

68Ga-DOTATATE PET/CT provides information on the location of somatostatin receptor–expressing tumors. Integrating this imaging data effectively in patient care requires the clinical history; the histopathology and biomarker information; and the grade, stage, and prior imaging results. Previous therapies and technical aspects of the study should be considered, given their ability to alter the interpretation of the images. This includes physiologic biodistribution of the radiotracer, as well as conditions that engender false-positive results. This article provides a guide to the performance and interpretation of 68Ga-DOTATATE PET/CT and describes its role in the diagnostic algorithm of neuroendocrine neoplasms and its overall utility in their management.



中文翻译:

神经内分泌肿瘤的68 Ga-DOTATATE成像中的当前概念:解释,生物分布,剂量学和分子策略。

68 Ga-DOTATATE PET / CT提供表达生长抑素受体的肿瘤位置的信息。有效地将此影像数据整合到患者护理中需要临床病史;组织病理学和生物标志物信息;以及等级,阶段和先前的成像结果。考虑到以前的治疗方法和研究的技术方面,应考虑其改变图像解释的能力。这包括放射性示踪剂的生理生物分布,以及引起假阳性结果的条件。本文为68 Ga-DOTATATE PET / CT的性能和解释提供了指南,并描述了其在神经内分泌肿瘤诊断算法中的作用及其在治疗中的整体效用。

更新日期:2017-11-01
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