Infectious diseases and cancers are leading causes of death and pose major challenges to public health. The human peptidome encompasses millions of compounds that display an enormous structural and functional diversity and represents an excellent source for the discovery of endogenous agents with antimicrobial and/or anticancer activity. Here, we discuss how to exploit the human peptidome for novel antimicrobial and anticancer agents through the generation of peptide libraries from human body fluids and tissues and stepwise purification of bioactive compounds.

中文翻译：

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利用人类肽组开发新型抗微生物剂和抗癌药

传染病和癌症是主要的死亡原因，对公共卫生构成重大挑战。人肽组包含数百万种化合物，这些化合物显示出巨大的结构和功能多样性，是发现具有抗菌和/或抗癌活性的内源性药物的绝佳来源。在这里，我们讨论如何通过从人体液体和组织中生成肽库以及逐步纯化生物活性化合物来利用人类肽组来开发新型抗微生物剂和抗癌剂。