A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.

中文翻译：

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TYRP1 mRNA可以捕获黑色素瘤中的miRNA。

已经报道了多种非编码RNA作为用于调节癌症的miRNA的内源海绵。然而，对具有蛋白质编码功能的转录本捕获miRNA的了解较少。现在发现TYRP1的mRNA可以隔离黑色素瘤非典型miRNA反应元件上的抑癌基因miR-16，从而促进恶性肿瘤的生长。