Fluoroform (CHF₃) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity of fluoroform, only very few applications have been reported so far. Herein we report a continuous flow difluoromethylation protocol on sp³ carbons employing fluoroform as a reagent. The protocol is applicable for the direct C^α-difluoromethylation of protected α-amino acids, and enables a highly atom efficient synthesis of the active pharmaceutical ingredient eflornithine.

中文翻译：

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氟仿连续流动中二氟甲基化的应用：α-二氟甲基氨基酸的简明合成

氟仿（CHF ₃）被认为是二氟甲基化反应的理想试剂。然而，由于氟仿的低反应性，迄今为止仅报道了很少的应用。在本文中，我们报告了使用氟仿作为试剂在sp ³碳上连续流动的二氟甲基化方案。该协议是适用于直接Ç ^α保护的α氨基酸的-difluoromethylation，并且使活性药物成分依氟鸟氨酸的高度原子有效合成。