The most striking and general property of the biological fibrous architectures in the extracellular matrix (ECM) is the strong and directional interaction between biologically active protein subunits. These fibers display rich dynamic behavior without losing their architectural integrity. The complexity of the ECM taking care of many essential properties has inspired synthetic chemists to mimic these properties in artificial one-dimensional fibrous structures with the aim to arrive at multi-component biomaterials. Due to the dynamic character required for interaction with natural tissue, supramolecular biomaterials are promising candidates for regenerative medicine. Depending on the application area, and thereby the design criteria of these multi-component fibrous biomaterials, they are used as elastomeric materials or hydrogel systems. Elastomeric materials are designed to have load bearing properties whereas hydrogels are proposed to support in vitro cell culture. Although the chemical structures and systems designed and studied today are rather simple compared to the complexity of the ECM, the first examples of these functional supramolecular biomaterials reaching the clinic have been reported. The basic concept of many of these supramolecular biomaterials is based on their ability to adapt to cell behavior as a result of dynamic non-covalent interactions. In this review, we show the translation of one-dimensional supramolecular polymers into multi-component functional biomaterials for regenerative medicine applications.

中文翻译：

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从超分子聚合物到多组分生物材料

细胞外基质（ECM）中生物纤维结构最引人注目的和最普遍的特性是生物活性蛋白亚基之间的强力和定向相互作用。这些纤维表现出丰富的动态行为，而不会失去其结构完整性。考虑到许多基本特性的ECM的复杂性激发了合成化学家在人造一维纤维状结构中模仿这些特性的目的，旨在获得多组分生物材料。由于与天然组织相互作用所需的动力学特性，超分子生物材料有望成为再生医学的候选材料。根据应用领域以及这些多组分纤维生物材料的设计标准，它们可以用作弹性体材料或水凝胶体系。体外细胞培养。尽管今天设计和研究的化学结构和系统与ECM的复杂性相比相当简单，但是已经报道了这些功能性超分子生物材料进入临床的第一个例子。许多这些超分子生物材料的基本概念是基于它们由于动态非共价相互作用而适应细胞行为的能力。在这篇综述中，我们显示了将一维超分子聚合物翻译成多组分功能性生物材料用于再生医学的应用。