Proteins and their interactions in and out of cells must be well-orchestrated for the healthy functioning and regulation of the body. Even the slightest disharmony can cause diseases. Therapeutic peptides are short amino acid sequences (generally considered <50 amino acids) that can naturally mimic the binding interfaces between proteins and thus, influence protein–protein interactions. Because of their fidelity of binding, peptides are a promising next generation of personalized medicines to reinstate biological harmony. Peptides as a group are highly selective, relatively safe, and biocompatible. However, they are also vulnerable to many in vivo pharmacologic barriers limiting their clinical translation. Current advances in molecular, chemical, and nanoparticle engineering are helping to overcome these previously insurmountable obstacles and improve the future of peptides as active and highly selective therapeutics. In this review, we focus on self-assembled vehicles as nanoparticles to carry and protect therapeutic peptides through this journey, and deliver them to the desired tissue.

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用于治疗性肽递送的分子工程解决方案

蛋白质及其在细胞内外的相互作用必须经过精心编排，以确保身体的健康功能和调节。即使是最轻微的不和谐也会导致疾病。治疗性肽是短的氨基酸序列（通常认为小于50个氨基酸），可以自然地模拟蛋白质之间的结合界面，从而影响蛋白质之间的相互作用。由于具有保真性，肽是恢复生物和谐的有前途的下一代个性化药物。肽作为一组是高度选择性的，相对安全的和生物相容的。但是，它们还容易受到许多体内的伤害限制其临床翻译的药理学障碍。分子，化学和纳米颗粒工程技术的最新进展正在帮助克服这些以前无法克服的障碍，并改善肽作为活性和高选择性治疗剂的未来。在这篇综述中，我们专注于自组装载体作为纳米颗粒，以在此过程中携带和保护治疗性肽，并将其递送至所需的组织。