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Near-Infrared Light-Triggered Polymeric Nanomicelles for Cancer Therapy and Imaging
ACS Biomaterials Science & Engineering ( IF 5.8 ) Pub Date : 2017-10-30 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00648
Lei Li 1 , Xin Pang 1 , Gang Liu 1
Affiliation  

Early diagnosis and efficient therapy are very important for cancer management. Among the various intelligent delivery systems, near-infrared (NIR) light-triggered polymeric nanomicelles (PNMs) have emerged as a promising approach for imaging and photoactive delivery. This platform can be used for spatially and temporally controlled remote release of therapeutic payload molecules under NIR light irradiation. This review discusses the design and characteristics of PNMs as well as their recent application in imaging, drug delivery, and theranostics in photothermal and photodynamic therapy. The challenges and potential of PNMs in biomedical applications are also highlighted.

中文翻译:

近红外光触发高分子纳米素用于癌症治疗和成像

早期诊断和有效治疗对癌症的治疗非常重要。在各种智能传输系统中,近红外(NIR)光触发的聚合物纳米胶束(PNM)已经成为一种有前途的成像和光敏传输方法。该平台可用于在NIR光照射下对治疗有效载荷分子进行空间和时间控制的远程释放。这篇综述讨论了PNM的设计和特性,以及它们在光热和光动力疗法中的成像,药物输送和治疗学中的最新应用。也强调了PNM在生物医学应用中的挑战和潜力。
更新日期:2017-10-30
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