Cholangiocarcinoma — evolving concepts and therapeutic strategies

Nature Reviews Clinical Oncology, Published online: 10 October 2017; doi:10.1038/nrclinonc.2017.157

Cholangiocarcinoma, the second most common form of liver cancer after hepatocellular carcinoma, is a heterogeneous disease entity with a near-universal poor prognosis. Our understanding of the epidemiology and biology of cholangiocarcinoma is increasing, and importantly, potentially actionable molecular and immunological targets for novel therapies are increasingly being identified. Herein, the evolving developments in the epidemiology, pathogenesis, and management of cholangiocarcinoma are reviewed.

中文翻译：

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胆管癌—不断发展的概念和治疗策略

胆管癌—不断发展的概念和治疗策略

Nature Reviews Clinical Oncology，在线发布：2017年10月10日；doi：10.1038 / nrclinonc.2017.157

胆管癌是继肝细胞癌之后第二大最常见的肝癌形式，是一种异质性疾病，预后差强人意。我们对胆管癌的流行病学和生物学的理解正在增加，重要的是，越来越多的人发现了新疗法可能具有作用的分子和免疫学靶标。在本文中，回顾了胆管癌的流行病学，发病机理和治疗方法的发展。