Targeted therapies: Understanding tumour drug addiction

Nature Reviews Cancer, Published online: 25 October 2017; doi:10.1038/nrc.2017.98

Kong et al. report a mechanism that underlies tumour 'drug addiction' in melanoma cell lines and mouse models involving an ERK2-dependent phenotype switch, which might have clinical implications for the use of alternating treatment strategies with targeted therapies.

中文翻译：

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靶向疗法：了解肿瘤药物成瘾

靶向疗法：了解肿瘤药物成瘾

Nature Reviews Cancer，在线发表：2017年10月25日; doi：10.1038 / nrc.2017.98

孔等人。报告了一种机制，该机制是涉及ERK2依赖表型转换的黑色素瘤细胞系和小鼠模型中肿瘤“药物成瘾”的基础，这可能对靶向治疗的交替治疗策略的使用具有临床意义。