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New eremophilane and dichlororesorcinol derivatives produced by endophytes isolated from Ficus ampelas.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2017-Dec-01 , DOI: 10.1038/ja.2017.125
Yoshihito Shiono , Niken Istikhari Muslihah , Takuma Suzuki , Nanang Rudianto Ariefta , Chairil Anwar , Handojo Hadi Nurjanto , Takako Aboshi , Tetsuya Murayama , Keitaro Tawaraya , Takuya Koseki , Jun Yoshida , Narandulam Usukhbayar , Shota Uesugi , Ken-ichi Kimura

The novel compound, 11-O-methylpetasitol (1), was isolated from Penicillium sp. N-175-1, and two new compounds, cosmochlorins D (5) and E (6), were isolated from Phomopsis sp. N-125. In addition, three known eremophilane sesquiterpenes, sporogen-AO1 (2), petasol (3) and 6-dehydropetasol (4), were isolated from Penicillium sp. N-175-1. The structures of 1, 5 and 6 were elucidated by a combination of extensive spectroscopic analyses, including 2D NMR, high-resolution electrospray ionization time-of-flight mass spectrometry (HRESITOFMS) and chemical reactions. Compounds 2, 3, 5 and 6 exhibited cytotoxicity to HL60 and 2 and 3 to HeLa cells. Furthermore, 2 and 3 showed robust growth-restoring activity of a Saccharomyces cerevisiae (cdc2-1 rad9Δ) mutant strain, whereas 5 and 6 exhibited minor growth-restoring activity in this strain. Thus, these compounds may inhibit the growth of HL60 and HeLa cells by blocking the cell cycle, and they may be utilized as new lead compounds that act as inhibitors of survival signal transduction pathways.

中文翻译:

从无花果榕中分离出的内生菌产生了新的全草胺和二氯间苯二酚衍生物。

从青霉菌属菌种中分离出了新型化合物11-O-甲基芥子醇(1)。N-175-1,和两种新化合物,从四单孢菌属菌中分离得到了四氯四氢卟酚D(5)和E(6)。N-125。此外,从青霉菌中分离出三种已知的艾草倍半萜,孢子原-AO1(2),petasol(3)和6-dehydropetasol(4)。N-175-1。通过广泛的光谱分析(包括2D NMR,高分辨率电喷雾电离飞行时间质谱(HRESITOFMS)和化学反应)的组合,阐明了1、5和6的结构。化合物2、3、5和6对HL60和2和3对HeLa细胞表现出细胞毒性。此外,2和3显示了酿酒酵母(cdc2-1rad9Δ)突变株的强劲的恢复生长活性,而5和6在该菌株中显示出较小的生长恢复活性。因此,
更新日期:2017-10-30
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