Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. In this review, we evaluate the role of SCD1 isoform in the regulation of lipid and glucose metabolism in metabolic tissues. These highlights of recent findings are aimed toward advancing our understanding of the role of SCD1 in the development of metabolic diseases, which may help evaluate the possible health outcomes of modulating MUFA levels through targeting SCD1 activity.

中文翻译：

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深入了解 Stearoyl-CoA Desaturase-1 对全身代谢的调节

硬脂酰辅酶 A 去饱和酶 1 (SCD1) 是燃料代谢的中心调节剂，可能代表控制肥胖和相关代谢疾病（包括 2 型糖尿病和脂肪肝）进展的治疗靶点。SCD1 催化单不饱和脂肪酸 (MUFA) 的合成，主要是油酸和棕榈油酸，这对于控制高碳水化合物饮食引起的体重增加很重要。在这篇综述中，我们评估了 SCD1 同种型在代谢组织中脂质和葡萄糖代谢调节中的作用。最近发现的这些亮点旨在促进我们对 SCD1 在代谢疾病发展中的作用的理解，这可能有助于评估通过靶向 SCD1 活性调节 MUFA 水平的可能健康结果。