T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1hiCXCR5−CD4+T cells were recently identified in breast cancer (BC) and rheumatoid arthritis (RA) to have beneficial or detrimental roles, respectively, but are they inflammatory tissue effector TFH cells?

中文翻译：

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PD-1hiCXCR5-CD4 + TFH细胞在癌症中发挥防御作用，在关节炎中发挥作用

T滤泡辅助细胞（TFH）的特征在于它们的CXCR5阳性和归巢于次级淋巴器官（SLO）的B细胞滤泡。最近在乳腺癌（BC）和类风湿性关节炎（RA）中发现了功能可比和表型相似的PD-1hiCXCR5-CD4 + T细胞的扩展亚群分别具有有益或有害作用，但它们是炎性组织效应TFH细胞吗？