Obesity is a major health problem without satisfactory pharmacological treatment. A promising strategy is to promote energy dissipation by activating brown/beige adipose tissue. However, for this strategy to succeed it requires improving the transferability amongst cellular, murine, and human systems and bridging the gap between basic and clinical research.

中文翻译：

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“基础和应用产热研究”弥合差距

肥胖是一个主要的健康问题，没有令人满意的药物治疗。一个有前景的策略是通过激活棕色/米色脂肪组织来促进能量消散。然而，要使这一策略取得成功，它需要提高细胞、鼠类和人类系统之间的可转移性，并弥合基础研究和临床研究之间的差距。