Two consensus reports on Helicobacter pylori (Hp), published recently in Gut , summarise the role of Hp gastritis in upper GI diseases, including gastric cancer (GCA).1 2 Although Hp gastritis definitely increases the risk of GCA as suggested in both reports, Hp is, on the other hand, also associated with a notable low incidence of oesophageal cancer (EC), of both adenomatous and squamous type. In our earlier 15-year follow-up of a large population-based sample of males aged 50–65 years (n=12 016) from two Finnish cities, with or without Hp, diagnosed in 1994–1996 by serological (IgG) Hp test (Biohit HealthCare, Helsinki, Finland), 57 GCA cases were recorded in the study population by the nationwide Cancer Registry during the follow-up.3 Of these cancers, 50 were in men and seven in those with and without Hp, respectively. The relative standardised incidence ratio (RR) of GCA incidence in Hp positive compared with that in Hp-negative men, calculated with the Altman’s procedure, was 6.0 (95%CI 2.3 to 19.0). In …

中文翻译：

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芬兰 12 000 名感染或未感染幽门螺杆菌的中年男性的基于人群样本的 20 年随访中的食管癌发病率

最近发表在 Gut 杂志上的两份关于幽门螺杆菌 (Hp) 的共识报告总结了 Hp 胃炎在包括胃癌 (GCA) 在内的上消化道疾病中的作用。1 2 虽然 Hp 胃炎确实会增加 GCA 的风险，正如两份报告所建议的那样，另一方面，Hp 还与腺瘤型和鳞癌型食管癌 (EC) 的显着低发病率有关。在我们较早的 15 年随访中，对来自芬兰两个城市的 50-65 岁男性（n=12 016）的大型人群样本进行了 15 年的随访，这些男性在 1994-1996 年通过血清学 (IgG) Hp 诊断出有或没有 Hp测试（Biohit HealthCare，赫尔辛基，芬兰），全国癌症登记处在随访期间在研究人群中记录了 57 例 GCA 病例。3 在这些癌症中，50 例为男性，7 例分别为患有和未患有 Hp 的癌症。Hp 阳性与 Hp 阴性男性 GCA 发病率的相对标准化发病率 (RR)，用 Altman 程序计算，为 6.0（95%CI 2.3 至 19.0）。在 …