Miniaturized matrix solid-phase dispersion (MSPD) followed by liquid chromatography tandem mass spectrometry (LC–MS/MS) has been proposed for the simultaneous analysis of different classes of synthetic dyes in confectionery and cosmetics intended for or mostly consumed by children. Selected compounds include most of the permitted dyes as food additives as well as some of the most frequently used to color cosmetic products in accordance with the respective European directives. MSPD procedure was optimized by means of experimental design, allowing an effective, rapid and simple extraction of dyes with low sample and reagents consumption (0.1 g of sample and 2 mL of elution solvent). LC–MS/MS was optimized for good resolution, selectivity and sensitivity using a low ionic strength mobile phase (3 mM NH₄Ac-methanol). Method performance was demonstrated in real samples showing good linearity (R ≥ 0.9928) and intra- and inter-day precision (%RSD ≤ 15%). Method LODs were ≤0.952 μg g⁻¹ and ≤0.476 μg g⁻¹ for confectionery and cosmetic samples, respectively. Recoveries of compounds from nine different matrices were quantitative. The validated method was successfully applied to 24 commercial samples (14 cosmetics and 10 foods) in which 9 of the selected dyes were found at concentrations up to 989 μg g⁻¹, exceeding in some cases the regulated maximum permitted limits. A non-permitted dye, Acid Orange 7, was found in one candy.

为了同时分析供儿童食用或主要供儿童食用的糖果和化妆品中不同类别的合成染料，已提出了微型化基质固相分散体（MSPD），然后进行液相色谱串联质谱分析（LC-MS / MS）的建议。根据相应的欧洲指令，选定的化合物包括大多数允许用作食品添加剂的染料，以及一些最常用于对化妆品进行着色的染料。通过实验设计优化了MSPD程序，可实现高效，快速和简单的染料提取，同时减少样品和试剂的消耗（0.1 g样品和2 mL洗脱溶剂）。LC-MS / MS使用低离子强度流动相（3 mM NH _4）进行了优化，以实现良好的分离度，选择性和灵敏度乙甲醇）。在具有良好线性（R≥0.9928）和日内和日间精度（％RSD≤15％）的真实样品中证明了方法的性能。对于糖果和化妆品样品，方法的检测限分别为≤0.952μgg ^-1和≤0.476μgg ^-1。从九种不同基质中回收的化合物是定量的。经验证的方法已成功应用于24个商业样品（14种化妆品和10种食品），其中发现9种选定染料的浓度高达989μgg ^-1，在某些情况下超过了规定的最大允许限值。在一个糖果中发现了一种不允许的染料，酸性橙7。