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Determination of Alkyl-Donor Promiscuity of Tyrosine-O-Prenyltransferase SirD from Leptosphaeria maculans
ChemBioChem ( IF 3.2 ) Pub Date : 2017-10-27 02:00:52 , DOI: 10.1002/cbic.201700469 Chandrasekhar Bandari 1 , Erin M. Scull 1 , Johanna M. Masterson 1 , Rachel H. Q. Tran 1 , Steven B. Foster 1 , Kenneth M. Nicholas 1 , Shanteri Singh 1
ChemBioChem ( IF 3.2 ) Pub Date : 2017-10-27 02:00:52 , DOI: 10.1002/cbic.201700469 Chandrasekhar Bandari 1 , Erin M. Scull 1 , Johanna M. Masterson 1 , Rachel H. Q. Tran 1 , Steven B. Foster 1 , Kenneth M. Nicholas 1 , Shanteri Singh 1
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The alkyl donor scope of tyrosine-O-prenyltransferase SirD has been determined by use of 21 synthetic alkyl pyrophosphate analogues, and the corresponding O-alkylated tyrosine products have been characterized by NMR. The study highlights SirD as highly promiscuous towards unnatural alkyl donors and provides insight into steric factors that impact the alkyl chain selectivity.
中文翻译:
黄斑狼疮杆菌酪氨酸-O-戊基转移酶SirD的烷基供体混杂度的测定
酪氨酸-O-异戊烯基转移酶SirD的烷基供体范围已通过使用21种合成的烷基焦磷酸类似物确定,相应的O-烷基化酪氨酸产物已通过NMR表征。该研究强调了SirD与非天然烷基供体高度混杂,并提供了影响烷基链选择性的空间因素的见解。
更新日期:2017-10-27
中文翻译:
黄斑狼疮杆菌酪氨酸-O-戊基转移酶SirD的烷基供体混杂度的测定
酪氨酸-O-异戊烯基转移酶SirD的烷基供体范围已通过使用21种合成的烷基焦磷酸类似物确定,相应的O-烷基化酪氨酸产物已通过NMR表征。该研究强调了SirD与非天然烷基供体高度混杂,并提供了影响烷基链选择性的空间因素的见解。