Cyclodextrins (CDs) are one of the most versatile substances produced by nature, and it is in the aqueous biological environment where the multifaceted potential of CDs can be completely unveiled. CDs form inclusion complexes with a variety of guest molecules, including polymers, producing very diverse biocompatible supramolecular structures. Additionally, CDs themselves can trigger cell differentiation to distinct lineages depending on the substituent groups and also promote salt nucleation. These features together with the affinity-driven regulated release of therapeutic molecules, growth factors and gene vectors explain the rising interest for CDs as building blocks in regenerative medicine. Supramolecular poly(pseudo)rotaxane structures and zipper-like assemblies exhibit outstanding viscoelastic properties, performing as syringeable implants. The sharp shear-responsiveness of the supramolecular assemblies is opening new avenues for the design of bioinks for 3D printing and also of electrospun fibers. CDs can also be transformed into polymerizable monomers to prepare alternative nanostructured materials. The aim of this review is to analyze the role that CDs may play in regenerative medicine through the analysis of the last decade research. Most applications of CD-based scaffolds are focussed on non-healing bone fractures, cartilage reparation and skin recovery, but also on even more challenging demands such as neural grafts. For the sake of clarity, main sections of this review are organized according to the architecture of the CD-based scaffolds, mainly syringeable supramolecular hydrogels, 3D printed scaffolds, electrospun fibers, and composites, since the same scaffold type may find application in different tissues.

环糊精（CDs）是自然界生产的用途最广泛的物质之一，在水性生物环境中，CD的多方面潜力可以被完全揭示出来。CD与多种客体分子（包括聚合物）形成包涵体复合物，从而产生非常多样化的生物相容性超分子结构。另外，CD本身可以根据取代基的种类触发细胞分化为不同的谱系，并且还促进了盐的成核作用。这些特征以及治疗分子，生长因子和基因载体的亲和力驱动型调节释放，解释了CD作为再生医学的基础材料的兴趣日益浓厚。超分子聚（假）轮烷结构和拉链状组件表现出出色的粘弹性，可作为可植入植入物使用。超分子组件的敏锐的剪切响应性为3D打印以及电纺纤维的生物油墨设计开辟了新途径。CD也可以转化为可聚合的单体，以制备替代的纳米结构材料。这篇综述的目的是通过对过去十年研究的分析来分析CD在再生医学中可能发挥的作用。基于CD的支架的大多数应用都集中在不愈合的骨折，软骨修复和皮肤恢复上，而且还集中在更具挑战性的要求上，例如神经移植。为了清楚起见，本综述的主要部分根据基于CD的支架的结构进行组织，主要是可注射的超分子水凝胶，3D打印的支架，电纺纤维和复合材料，