A strategy for the synthesis of sequence‐defined oligomers using a selective side‐group insertion approach making use of thiophenol‐catalyzed amidation reactions is herein reported. In this context, a new thiolactone‐based, multistep, iterative protocol is designed, utilizing thioacrylates in combination with solid‐phase synthesis for step‐by‐step growth, resulting in sequence‐defined oligomers. Sequence definition and structure variation are introduced by substituting the thioacrylate side groups with a wide variety of amines. The step‐by‐step growth of the oligomers is followed by liquid chromatography–mass spectrometry and high‐resolution mass spectroscopy to determine both conversion and purity.

中文翻译：

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在通用的，顺序确定的程序中对硫代丙烯酸酯进行量身定制的改性

本文报道了一种利用硫代苯酚催化的酰胺化反应的选择性侧基插入方法合成序列定义的低聚物的策略。在这种情况下，设计了一种新的基于硫代内酯的多步迭代方案，该方法将硫代丙烯酸酯与固相合成相结合以逐步生长，从而产生序列定义的低聚物。通过用多种胺取代硫代丙烯酸酯侧基来引入序列定义和结构变化。在低聚物逐步生长之后，进行液相色谱-质谱和高分辨质谱分析，以确定转化率和纯度。