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ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Nature Medicine ( IF 82.9 ) Pub Date : 2017-10-23 , DOI: 10.1038/nm.4419 David Lagares , Parisa Ghassemi-Kakroodi , Caroline Tremblay , Alba Santos , Clemens K Probst , Alicia Franklin , Daniela M Santos , Paula Grasberger , Neil Ahluwalia , Sydney B Montesi , Barry S Shea , Katharine E Black , Rachel Knipe , Meryem Blati , Murray Baron , Brian Wu , Hassan Fahmi , Rajiv Gandhi , Annie Pardo , Moisés Selman , Jiangping Wu , Jean-Pierre Pelletier , Johanne Martel-Pelletier , Andrew M Tager , Mohit Kapoor
Nature Medicine ( IF 82.9 ) Pub Date : 2017-10-23 , DOI: 10.1038/nm.4419 David Lagares , Parisa Ghassemi-Kakroodi , Caroline Tremblay , Alba Santos , Clemens K Probst , Alicia Franklin , Daniela M Santos , Paula Grasberger , Neil Ahluwalia , Sydney B Montesi , Barry S Shea , Katharine E Black , Rachel Knipe , Meryem Blati , Murray Baron , Brian Wu , Hassan Fahmi , Rajiv Gandhi , Annie Pardo , Moisés Selman , Jiangping Wu , Jean-Pierre Pelletier , Johanne Martel-Pelletier , Andrew M Tager , Mohit Kapoor
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
中文翻译：
ADAM10介导的ephrin-B2脱落促进成肌纤维细胞活化和器官纤维化
ADAM10介导的ephrin-B2脱落促进成肌纤维细胞活化和器官纤维化
更新日期：2017-10-25
Nature Medicine, Published online: 23 October 2017; doi:10.1038/nm.4419
TGF-β induces expression of ADAM10, which results in greater shedding of ephrin-B2. This shedding promotes the chemotaxis and activation of myofibroblasts and thus the progression of organ fibrosis.
中文翻译：
ADAM10介导的ephrin-B2脱落促进成肌纤维细胞活化和器官纤维化
ADAM10介导的ephrin-B2脱落促进成肌纤维细胞活化和器官纤维化
《自然医学》（Nature Medicine），在线发布：2017年10月23日; doi：10.1038 / nm.4419
TGF-β诱导ADAM10的表达，从而导致ephrin-B2的脱落更大。这种脱落促进成肌纤维细胞的趋化性和活化，从而促进器官纤维化的发展。
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