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EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
Nature Cell Biology ( IF 21.3 ) Pub Date : 2017-10-23 , DOI: 10.1038/ncb3628 Zarah M. Löf-Öhlin,Pia Nyeng,Matthew E. Bechard,Katja Hess,Eric Bankaitis,Thomas U. Greiner,Jacqueline Ameri,Christopher V. Wright,Henrik Semb
Nature Cell Biology ( IF 21.3 ) Pub Date : 2017-10-23 , DOI: 10.1038/ncb3628 Zarah M. Löf-Öhlin,Pia Nyeng,Matthew E. Bechard,Katja Hess,Eric Bankaitis,Thomas U. Greiner,Jacqueline Ameri,Christopher V. Wright,Henrik Semb
EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
中文翻译:
EGFR信号传导通过调节apapobasal极性控制细胞命运和胰腺器官发生
EGFR信号传导通过调节apapobasal极性控制细胞命运和胰腺器官发生
更新日期:2017-10-25
Nature Cell Biology, Published online: 23 October 2017; doi:10.1038/ncb3628
In the developing mouse pancreas, EGFR regulates apical polarity via PI(3)K and Rac1 and elicits different ligand-dependent effects: BTC enables β-cell commitment and EGF inhibits polarization of epithelial progenitors during the primary transition.
中文翻译:
EGFR信号传导通过调节apapobasal极性控制细胞命运和胰腺器官发生
EGFR信号传导通过调节apapobasal极性控制细胞命运和胰腺器官发生
《自然细胞生物学》,在线发布:2017年10月23日; doi:10.1038 / ncb3628
在发育中的小鼠胰腺中,EGFR通过PI(3)K和Rac1调节顶极极性,并引起不同的配体依赖性效应:BTC使β细胞发挥作用,而EGF在主要过渡过程中抑制上皮祖细胞的极化。