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Metal-catalyzed enyne cycloisomerization in natural product total synthesis
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1039/c7qo00702g Ying Hu 1, 2, 3, 4 , Miao Bai 1, 2, 3, 4 , Ying Yang 1, 2, 3, 4 , Qianghui Zhou 1, 2, 3, 4, 5
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-09-18 00:00:00 , DOI: 10.1039/c7qo00702g Ying Hu 1, 2, 3, 4 , Miao Bai 1, 2, 3, 4 , Ying Yang 1, 2, 3, 4 , Qianghui Zhou 1, 2, 3, 4, 5
Affiliation
Since the seminal work of B. M. Trost et al. in 1985, metal catalyzed enyne cycloisomerization has become a fast growing and fascinating field. Due to its diversified chemistry and ability to increase molecular complexity in an efficient, atom economical, step economic and redox economic way, enyne cycloisomerization has become a powerful and attractive strategy for the construction of cyclic compounds, and thus has great potential for applications in total synthesis of natural products and pharmaceuticals. In this review, a brief summary of the state-of-the-art mechanism studies, the classification of structures accessed through enyne cycloisomerizations, and recent completed total synthesis of representative natural products showcasing creative and ingenious incorporation of enyne cycloisomerization as a strategic manoeuver are included, with the aim of providing a complement to the existing reviews to inspire future developments.
中文翻译:
天然产物全合成中金属催化的烯炔环异构化
由于BM Trost等人的开创性工作。1985年,金属催化的烯炔环异构化已成为一个快速发展且引人入胜的领域。由于其多样化的化学性质和以高效,原子经济,阶梯经济和氧化还原经济的方式增加分子复杂性的能力,烯炔环异构化已成为构建环状化合物的有力且有吸引力的策略,因此在总体上具有广阔的应用前景天然产物和药物的合成。在这篇综述中,简要概述了最新的机理研究,通过烯炔环异构化获得的结构的分类以及最近完成的代表性天然产物的全合成,这些研究表明创造性地和巧妙地将烯炔环异构化纳入了战略策略。包括,
更新日期:2017-10-25
中文翻译:
天然产物全合成中金属催化的烯炔环异构化
由于BM Trost等人的开创性工作。1985年,金属催化的烯炔环异构化已成为一个快速发展且引人入胜的领域。由于其多样化的化学性质和以高效,原子经济,阶梯经济和氧化还原经济的方式增加分子复杂性的能力,烯炔环异构化已成为构建环状化合物的有力且有吸引力的策略,因此在总体上具有广阔的应用前景天然产物和药物的合成。在这篇综述中,简要概述了最新的机理研究,通过烯炔环异构化获得的结构的分类以及最近完成的代表性天然产物的全合成,这些研究表明创造性地和巧妙地将烯炔环异构化纳入了战略策略。包括,