A palladium/nickel catalyzed selective N–H/C–H methylation of amides by using peroxides is described, providing N-methylation products and C-methylation products in moderate to good yields. In this procedure, peroxides play a dual role, serving as both the methyl source and radical initiator. This protocol tolerated a broad range of substrates, not only various sulfonamides but also methanamides. Mechanistic investigations involving a radical process are also described.

中文翻译：

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Pd / Ni通过自由基过程将过氧化物用作甲基化试剂来催化酰胺的选择性N–H / C–H甲基化

描述了钯/镍通过使用过氧化物催化酰胺的选择性N–H / C–H甲基化，以中等到良好的产率提供了N-甲基化产物和C-甲基化产物。在此过程中，过氧化物起着双重作用，既充当甲基来源，又充当自由基引发剂。该方案可耐受多种底物，不仅包括各种磺酰胺类，而且还包括甲酰胺类。还介绍了涉及彻底过程的机械研究。