Natural product libraries contain specialized metabolites derived from plants, animals, and microorganisms that play a pivotal role in drug discovery due to their immense structural diversity and wide variety of biological activities. The strategies to greatly extend natural product scaffolds through available biological and chemical approaches offer unique opportunities to access a new series of natural product analogues, enabling the construction of diverse natural product‐like libraries. The affordability of these structurally diverse molecules has been a crucial step in accelerating drug discovery. This review provides an overview of various approaches to exploit the diversity of compounds for natural product‐based drug development, drawing upon a series of examples to illustrate each strategy.

中文翻译：

---

使天然产物多样化以进行药物开发的策略

天然产物库包含衍生自植物，动物和微生物的专门代谢产物，这些代谢产物由于其巨大的结构多样性和广泛的生物活性而在药物开发中起着举足轻重的作用。通过可用的生物学和化学方法大大扩展天然产物支架的策略为访问一系列新的天然产物类似物提供了独特的机会，从而能够构建各种类似于天然产物的文库。这些结构多样的分子的可负担性一直是加速药物发现的关键步骤。本文通过一系列实例说明每种策略，概述了利用多种化合物开发基于天然产物的药物的各种方法。