Synaptic neurotransmission relies on maintenance of the synapse and meeting the energy demands of neurons. Defects in excitatory and inhibitory synapses have been implicated in schizophrenia, likely contributing to positive and negative symptoms as well as impaired cognition. Recently, accumulating evidence has suggested that bioenergetic systems, important in both synaptic function and cognition, are abnormal in psychiatric illnesses such as schizophrenia. Animal models of synaptic dysfunction demonstrated endophenotypes of schizophrenia as well as bioenergetic abnormalities. We report findings on the bioenergetic interplay of astrocytes and neurons and discuss how dysregulation of these pathways may contribute to the pathogenesis of schizophrenia, highlighting metabolic systems as important therapeutic targets.

中文翻译：

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精神分裂症生物能耦合缺陷

突触神经传递依赖于突触的维持并满足神经元的能量需求。兴奋性和抑制性突触的缺陷与精神分裂症有关，可能导致阳性和阴性症状以及认知受损。最近，越来越多的证据表明，对突触功能和认知都很重要的生物能量系统在精神分裂症等精神疾病中存在异常。突触功能障碍的动物模型表现出精神分裂症的内表型以及生物能异常。我们报告了星形胶质细胞和神经元生物能相互作用的发现，并讨论了这些途径的失调如何导致精神分裂症的发病机制，强调代谢系统作为重要的治疗靶点。