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Novel poly(vinyl alcohol)-based amphiphilic nanogels by non-covalent boric acid crosslinking of polymeric micelles
Biomaterials Science ( IF 6.6 ) Pub Date : 2017-09-21 00:00:00 , DOI: 10.1039/c7bm00675f
Hen Moshe 1, 2, 3, 4, 5 , Yuval Davizon 1, 2, 3, 4, 5 , Maya Menaker Raskin 1, 2, 3, 4, 5 , Alejandro Sosnik 1, 2, 3, 4, 5
Affiliation  

In this work, we report a new type of poly(vinyl alcohol)-g-poly(N-isopropylacrylamide) (PVA-g-PNiPAAm) amphiphilic nanogel produced by the non-covalent crosslinking of PVA polyol domains in preformed polymeric micelles with boric acid. The nanomaterials showed sizes in the 100–250 nm range (DLS) and a spherical morphology (HR-SEM). We demonstrated that the size of the polymeric micelles could be fine-tuned by changing the concentration (and the aggregation pattern) of the polymeric amphiphile in water. Upon crosslinking, the polymeric micelles turned into physically stable amphiphilic nanogels that displayed both size and size distribution similar to the micellar precursor for up to two weeks, even under disfavored conditions of concentration and temperature that, in the case of non-crosslinked counterparts, resulted in quick disassembly. In addition, we show for the first time the feasibility of spray-drying technology to consolidate the 3D network formed between PVA and boric acid and to produce stable powders that can be reconstituted upon use at any desired concentration. Moreover, the formation of a borated surface conferred the nanogels with good mucoadhesiveness in vitro. Finally, these novel nanomaterials showed optimal cell compatibility in a model of the intestinal epithelium, the Caco2 cell line. Overall results demonstrate the unprecedented versatility of the proposed modular approach and opens completely new horizons in the application of polymeric micelles and other self-assembled polymeric nanomaterials in diagnostics and therapeutics.

中文翻译:

高分子胶束非共价硼酸交联的新型基于聚乙烯醇的两亲纳米凝胶

在这项工作中,我们报告了一种新型的聚乙烯醇-g-N-异丙基丙烯酰胺(PVA- g-PNiPAAm)两性纳米凝胶,是通过预先形成的聚合物胶束中的PVA多元醇结构域与硼酸进行非共价交联而制得的。纳米材料的尺寸在100–250 nm范围(DLS)和球形形态(HR-SEM)。我们证明了可以通过改变水中聚合物两亲物的浓度(和聚集模式)来微调聚合物胶束的大小。交联后,聚合物胶束变成物理稳定的两亲性纳米凝胶,即使在浓度和温度不利的情况下(即使在非交联的情况下,也会产生类似于胶束前体的大小和尺寸分布)长达两周。快速拆卸。此外,我们首次展示了喷雾干燥技术巩固PVA和硼酸之间形成的3D网络以及生产稳定的粉末的可行性,该粉末可以在使用时以任何所需的浓度重新配制。而且,形成硼酸化的表面使纳米凝胶具有良好的粘膜粘附性体外。最后,这些新型纳米材料在肠上皮模型Caco2细胞系中显示出最佳的细胞相容性。总体结果表明,所提出的模块化方法具有前所未有的多功能性,并为聚合物胶束和其他自组装聚合物纳米材料在诊断和治疗中的应用开辟了崭新的前景。
更新日期:2017-10-24
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