We thank van Baar et al. (1) for their interest in our study (2). We agree that the chronic natriuretic effect(s) of the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin occurred in the early postprandial state (3 h after a standardized liquid meal during a euglycemic clamp). We cannot, however, rule out that DPP-4 inhibitor–mediated effect(s) on natriuresis persisted for several hours after this sampling period. Recognizing feasibility concerns around having research participants in a highly controlled research setting for prolonged periods, we limited our fractional sodium excretion (FENA) and renal hemodynamic function measurements to 3 h. This was in addition to the 4–5 h that patients had already been in the lab for baseline testing. We agree that …

中文翻译：

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对Lovshin等人评论的回应。二肽基肽酶4抑制作用可刺激2型糖尿病患者远端肾小管利尿和循环SDF- ^1α1-67的升高。糖尿病护理2017; 40：1073-1081

我们感谢van Baar等。（1）对他们对我们研究的兴趣（2）。我们同意，二肽基肽酶4（DPP-4）抑制剂西他列汀的慢性利钠钠作用发生在餐后早期（在正常血糖钳制后的标准液体餐后3小时）。但是，我们不能排除DPP-4抑制剂介导的利钠作用在该采样期后持续了几个小时。认识到围绕研究对象长期处于高度受控的研究环境中的可行性问题，我们将分数钠排泄（FENA）和肾血流动力学功能的测量值限制在3小时以内。这是患者已经在实验室进行基线测试的4-5小时的补充。我们同意...