Uncovering the parts of a whole: The biosynthetic pathway of pleuromutilin has been elucidated by in vitro enzymatic reactions and biotransformation experiments. Labdane-related diterpene synthase Ple3 and five modification enzymes, three cytochrome P450s (Ple156), a dehydrogenase (Ple7), and an acetyltransferase (Ple2), have been functionally characterized.

中文翻译：

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担子菌真菌中分离的二萜截短侧耳素的生物合成机制

揭示整体的组成部分：截短侧耳素的生物合成途径已通过体外酶促反应和生物转化实验得以阐明。Labdane相关的二萜合酶Ple3和5种修饰酶，3种细胞色素P450（Ple156），脱氢酶（Ple7）和乙酰基转移酶（Ple2）已进行了功能鉴定。