Recent advances and applications of biomolecule‐responsive hydrogels, namely, glucose‐responsive hydrogels, protein‐responsive hydrogels, and nucleic‐acid‐responsive hydrogels are highlighted. However, achieving the ultimate purpose of using biomolecule‐responsive hydrogels in preclinical and clinical areas is still at the very early stage and calls for more novel designing concepts and advance ideas. On the way toward the real/clinical application of biomolecule‐responsive hydrogels, plenty of factors should be extensively studied and examined under both in vitro and in vivo conditions. For example, biocompatibility, biointegration, and toxicity of biomolecule‐responsive hydrogels should be carefully evaluated. From the living body's point of view, biocompatibility is seriously depended on the interactions at the tissue/polymer interface. These interactions are influenced by physical nature, chemical structure, surface properties, and degradation of the materials. In addition, the developments of advanced hydrogels with tunable biological and mechanical properties which cause no/low side effects are of great importance.

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生物分子响应水凝胶在医学中

着重介绍了生物分子响应性水凝胶，即葡萄糖响应性水凝胶，蛋白质响应性水凝胶和核酸响应性水凝胶的最新进展和应用。然而，在临床前和临床领域中达到使用生物分子反应性水凝胶的最终目的仍处于早期阶段，需要更新颖的设计理念和先进的思想。在生物分子响应水凝胶真正/临床应用的过程中，应在体外和体内条件下对许多因素进行广泛研究和检查。例如，应仔细评估生物分子响应水凝胶的生物相容性，生物整合性和毒性。从活体的角度来看，生物相容性严重取决于组织/聚合物界面的相互作用。这些相互作用受物理性质，化学结构，表面性质和材料降解的影响。另外，具有不引起/低副作用的可调节的生物学和机械性质的高级水凝胶的开发也非常重要。