-
Discrepancies between transcutaneous and estimated glomerular filtration rates in rats with chronic kidney disease Kidney Int. (IF 19.6) Pub Date : 2024-03-19 Tobias T. Pieters, Paul J. Besseling, Dominique M. Bovée, Maarten B. Rookmaaker, Marianne C. Verhaar, Benito Yard, Ewout J. Hoorn, Jaap A. Joles
Accurate assessment of the glomerular filtration rate (GFR) is crucial for researching kidney disease in rats. Although validation of methods that assess GFR is crucial, large-scale comparisons between different methods is lacking. Both transcutaneous GFR (tGFR) and a newly developed estimated GFR (eGFR) equation by our group provide a low-invasive approach enabling repeated measurements. The tGFR
-
Cutting back on low-value healthcare practices supports sustainable kidney care Kidney Int. (IF 19.6) Pub Date : 2024-03-19 Scott McAlister PhD, Valerie A. Luyckx PhD, Andrea K. Viecelli PhD
July 2023 marked the hottest month on record, underscoring the urgent need for action on climate change. The imperative to reduce carbon emissions extends to all sectors including healthcare, with it being responsible for 5.5% of global emissions. In decarbonising healthcare, while much attention has focused on greening healthcare infrastructure and procurement, less attention has focused on reducing
-
Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by a 3-dimensional fast marching algorithm Kidney Int. (IF 19.6) Pub Date : 2024-03-06 Alexander M.C. Böhner, Alexander Effland, Alice M. Jacob, Karin A.M. Böhner, Zeinab Abdullah, Sebastian Brähler, Ulrike I. Attenberger, Martin Rumpf, Christian Kurts
-
The 14th International Podocyte Conference 2023: from podocyte biology to glomerular medicine Kidney Int. (IF 19.6) Pub Date : 2024-03-04 Sybille Koehler, Felicitas Hengel, Bernhard Dumoulin, Laurel Damashek, Lawrence B. Holzman, Katalin Susztak, Tobias B. Huber, International Podocyte Conference Organizing Committee
The 14th International Podocyte Conference took place in Philadelphia, Pennsylvania, USA from May 23 to 26, 2023. It commenced with an early-career researchers' meeting on May 23, providing young scientists with a platform to present and discuss their research findings. Throughout the main conference, 29 speakers across 9 sessions shared their insights on podocyte biology, glomerular medicine, novel
-
Apolipoprotein E is enriched in dense deposits and is a marker for dense deposit disease in C3 glomerulopathy Kidney Int. (IF 19.6) Pub Date : 2024-03-04 Benjamin Madden, Raman Deep Singh, Mark Haas, Lilian M.P. Palma, Alok Sharma, Maria J. Vargas, LouAnn Gross, Vivian Negron, Torell Nate, M. Cristine Charlesworth, Jason D. Theis, Samih H. Nasr, Karl A. Nath, Fernando C. Fervenza, Sanjeev Sethi
C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), both of which are characterized by bright glomerular C3 staining on immunofluorescence studies. However, on electron microscopy (EM), DDD is characterized by dense osmiophilic mesangial and intramembranous deposits
-
Development of PD in lower-income countries: a rational solution for the management of AKI and ESKD Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Brett Cullis, Mignon McCulloch, Fredric O. Finkelstein
It is estimated that >50% of patients with end-stage kidney disease (ESKD) in low-resource countries are unable to access dialysis. When hemodialysis is available, it often has high out-of-pocket expenditure and is seldom delivered to the standard recommended by international guidelines. Hemodialysis is a high-cost intervention with significant negative effects on environmental sustainability, especially
-
Assessment of epidemiology and outcomes of adult patients with kidney-limited thrombotic microangiopathies Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Valentin Maisons, Anna Duval, Laurent Mesnard, Marie Frimat, Fadi Fakhouri, Steven Grangé, Aude Servais, Claire Cartery, Laurent Fauchier, Paul Coppo, Dimitri Titeca-Beauport, Nicolas Fage, Yahsou Delmas, Anne-Hélène Quérard, Guillaume Seret, Mickaël Bobot, Moglie Le Quintrec, Simon Ville, Florent von Tokarski, Sophie Chauvet, Alain Wynckel, Manon Martins, Juliet Schurder, Christelle Barbet, Bénédicte
-
Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Evans O. Asowata, Simone Romoli, Rebecca Sargeant, Jennifer Y. Tan, Scott Hoffmann, Margaret M. Huang, Krishnaa T. Mahbubani, Fynn N. Krause, Daniel Jachimowicz, Rasmus Agren, Albert Koulman, Benjamin Jenkins, Barbara Musial, Julian L. Griffin, Magnus Soderberg, Stephanie Ling, Pernille B.L. Hansen, Kourosh Saeb-Parsy, Kevin J. Woollard
-
Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition Kidney Int. (IF 19.6) Pub Date : 2024-02-29 Jeonghwan Lee, Jinhaeng Lee, Kyuhong Kim, Jiwon Lee, Youngae Jung, Jin Seong Hyeon, Areum Seo, Wencheng Jin, Boram Weon, Nayeon Shin, Sejoong Kim, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee, Geum-Sook Hwang, Seung Hee Yang
-
Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis Kidney Int. (IF 19.6) Pub Date : 2024-02-28 Josep M. Cruzado, Anna Manonelles, Sandra Rayego, Núria Doladé, Ana Amaya-Garrido, Cristian Valera, Roser Guiteras, Jose Luis Mosquera, Michaela Jung, Sergi Codina, Laura Martínez-Valenzuela, Juliana Draibe, Carlos Couceiro, Francesc Vigués, Álvaro Madrid, M. Carolina Florian, Marta Ruíz-Ortega, Anna Sola
-
Paraspeckle protein NONO attenuates vascular calcification by inhibiting bone morphogenetic protein 2 transcription Kidney Int. (IF 19.6) Pub Date : 2024-02-27 Yue Lu, Linlin Meng, Ruiqing Ren, Xinlu Wang, Wenhai Sui, Fei Xue, Lin Xie, Ang Chen, Yuxia Zhao, Jianmin Yang, Wencheng Zhang, Xiao Yu, Bo Xi, Feng Xu, Meng Zhang, Yun Zhang, Cheng Zhang
-
Inhibition of transcriptional coactivator YAP Impairs the expression and function of transcription factor WT1 in diabetic podocyte injury Kidney Int. (IF 19.6) Pub Date : 2024-02-27 Jianchun Chen, Xiaoyong Wang, Qian He, Hai-Chun Yang, Agnes B. Fogo, Raymond C. Harris
-
Targeting WIP1 phosphatase promotes partial remission in experimental collapsing glomerulopathy Kidney Int. (IF 19.6) Pub Date : 2024-02-27 Lou C. Duret, Tynhinane Hamidouche, Nicholas J. Steers, Catherine Pons, Nicolas Soubeiran, Delphine Buret, Eric Gilson, Ali G. Gharavi, Vivette D. D’Agati, Marina Shkreli
-
A case-based narrative review of pregnancy-associated atypical hemolytic uremic syndrome/complement-mediated thrombotic microangiopathy Kidney Int. (IF 19.6) Pub Date : 2024-02-24 Michael Che, Sarah M. Moran, Richard J. Smith, Kevin Y.M. Ren, Graeme N. Smith, M. Khaled Shamseddin, Carmen Avila-Casado, Jocelyn S. Garland
Atypical hemolytic uremic syndrome is a complement-mediated thrombotic microangiopathy caused by uncontrolled activation of the alternative complement pathway in the setting of autoantibodies to or rare pathogenic genetic variants in complement proteins. Pregnancy may serve as a trigger and unmask atypical hemolytic uremic syndrome/complement-mediated thrombotic microangiopathy (aHUS/CM-TMA), which
-
Quantitative assessment of glomerular basement membrane collagen IV α chains in paraffin sections from patients with focal segmental glomerulosclerosis and Alport gene variants Kidney Int. (IF 19.6) Pub Date : 2024-02-22 Pongpratch Puapatanakul, Suramath Isaranuwatchai, Ankanee Chanakul, Jerasit Surintrspanont, Kroonpong Iampenkhae, Talerngsak Kanjanabuch, Kanya Suphapeetiporn, Vivek Charu, Hani Y. Suleiman, Kearkiat Praditpornsilpa, Jeffrey H. Miner
-
Disrupting circadian control of autophagy induces podocyte injury and proteinuria Kidney Int. (IF 19.6) Pub Date : 2024-02-21 Lulu Wang, Han Tian, Haiyan Wang, Xiaoming Mao, Jing Luo, Qingyun He, Ping Wen, Hongdi Cao, Li Fang, Yang Zhou, Junwei Yang, Lei Jiang
-
The role of desmoglein-2 in kidney disease Kidney Int. (IF 19.6) Pub Date : 2024-02-21 Tong Xu, Lea Herkens, Ting Jia, Barbara M. Klinkhammer, Sebastian Kant, Claudia A. Krusche, Eva M. Buhl, Sikander Hayat, Jürgen Floege, Pavel Strnad, Rafael Kramann, Sonja Djudjaj, Peter Boor
-
Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Management of ANCA–Associated Vasculitis Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Ethan M. Balk, Craig E. Gordon, Gaelen Adam, Marcello A. Tonelli, Michael Cheung, Amy Earley, Brad H. Rovin
-
Anti-nephrin antibodies in recurrence of focal segmental glomerulosclerosis: closer to discovering the Holy Grail? Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Marina Vivarelli, Manuela Colucci
-
-
The authors reply Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Wenjun Ju, Hiddo J.L. Heerspink, Matthias Kretzler, Petter Bjornstad
-
KDIGO 2024 Clinical Practice Guideline for the Management of Antineutrophil Cytoplasmic Antibody (ANCA)–Associated Vasculitis Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Brad H. Rovin
-
-
-
Bile cast nephropathy after sinusoidal obstruction syndrome Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Toshiki Terao, Kyosuke Horikawa, Ken-ichi Matsuoka
-
-
Mind the gap in kidney care: translating what we know into what we do Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Valerie A. Luyckx, Katherine R. Tuttle, Dina Abdellatif, Ricardo Correa-Rotter, Winston W.S. Fung, Agnès Haris, Li-Li Hsiao, Makram Khalife, Latha A. Kumaraswami, Fiona Loud, Vasundhara Raghavan, Stefanos Roumeliotis, Marianella Sierra, Ifeoma Ulasi, Bill Wang, Siu-Fai Lui, Vassilios Liakopoulos, Alessandro Balducci, Alessandro Balducci, Vassilios Liakopoulos, Li-Li Hsiao, Ricardo Correa-Rotter, Ifeoma
-
-
Sodium-glucose cotransporter 2 inhibition, epidermal growth factor, and magnesium homeostasis: is there a link? Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Chintan V. Shah
-
-
Sodium-glucose cotransporter 2 inhibitors in the treatment of refractory hypomagnesemia Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Armando Luis Negri
-
Exploring nontraditional cardiorenal advantages of SGLT-2 inhibitors and GLP-1 receptor agonists Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Jia-Jin Chen, Tao-Han Lee, Huang-Yu Yang
-
-
Advancing parathyroid anatomy understanding through single-cell RNA sequencing in uremic secondary hyperparathyroidism Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Iddo Z. Ben-Dov
-
APOL1-mediated and Mendelian forms of “heretofore” idiopathic collapsing glomerulopathy: lessons from Brazil Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Nicholette D. Palmer, Barry I. Freedman
-
A Neanderthal haplotype introgressed into the human genome confers protection against membranous nephropathy Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Cătălin D. Voinescu, Monika Mozere, Giulio Genovese, Mallory L. Downie, Sanjana Gupta, Daniel P. Gale, Detlef Bockenhauer, Robert Kleta, Mauricio Arcos-Burgos, Horia C. Stanescu
Class 2 HLA and PLA2R1 alleles are exceptionally strong genetic risk factors for membranous nephropathy (MN), leading, through an unknown mechanism, to a targeted autoimmune response. Introgressed archaic haplotypes (introduced from an archaic human genome into the modern human genome) might influence phenotypes through gene dysregulation. Here, we investigated the genomic region surrounding the PLA2R1
-
Refining GFR estimation: a quest for the unobservable truth? Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Tariq Shafi
-
-
Mining the amyloid-plaque proteome to uncover disease mechanisms in renal amyloidoses Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Mario Nuvolone, Giampaolo Merlini
-
-
Alternative creatinine-based GFR estimates in United States populations—similar performance, same gaps—is it time to move on? Kidney Int. (IF 19.6) Pub Date : 2024-02-20 June Fabian
-
The Case | A patient with skin rash, monoclonal gammopathy, and proteinuria Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Justyna Fryc, Beata Naumnik
-
-
In remembrance of Eberhard Ritz, MD (1938–2023) Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Kai-Uwe Eckardt, Kerstin Amann
-
Gene editing: a near future for the treatment of genetic kidney diseases Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Fernando Gómez-García, Miguel A. Garcia-Gonzalez
-
Reconstructing the interface between the human intestine and immune system: potential to advance mechanistic studies in IgA nephropathy Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Huamin Wang, James Zuiani, P. Toby Coates AO, Yun Xia
-
Cardiac tamponade diagnosed on nephrologist-performed point-of-care ultrasonography Kidney Int. (IF 19.6) Pub Date : 2024-02-20 Aisha Batool, Abhilash Koratala
-
Reassuring pregnancy outcomes in women with mild COL4A3-5–related disease (Alport syndrome) and genetic type of disease can aid personalized counseling Kidney Int. (IF 19.6) Pub Date : 2024-02-19 Margriet E. Gosselink, Rozemarijn Snoek, Agne Cerkauskaite-Kerpauskiene, Sophie P.J. van Bakel, Renee Vollenberg, Henk Groen, Rimante Cerkauskiene, Marius Miglinas, Rossella Attini, Kálmán Tory, Kathleen J. Claes, Kristel van Calsteren, Aude Servais, Margriet F.C. de Jong, Valentine Gillion, Liffert Vogt, Antonio Mastrangelo, Monica Furlano, Roser Torra, Kate Bramham, Kate Wiles, Elizabeth R. Ralston
-
An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH) Kidney Int. (IF 19.6) Pub Date : 2024-02-15 Zewu Zhu, Bryan Bo-Ran Ho, Alyssa Chen, James Amrhein, Andreea Apetrei, Thomas Oliver Carpenter, Marise Lazaretti-Castro, Juan Manuel Colazo, Kathryn McCrystal Dahir, Michaela Geßner, Evgenia Gurevich, Cathrine Alsaker Heier, Jill Hickman Simmons, Tracy Earl Hunley, Bernd Hoppe, Christina Jacobsen, Anne Kouri, Nina Ma, Sachin Majumdar, Arnaud Molin, Natalie Nokoff, Susan M. Ott, Helena Gil Peña, Fernando
-
An open label non-inferiority randomized control trial evaluated alternate day prednisolone given daily during infections vs. levamisole in frequently relapsing nephrotic syndrome Kidney Int. (IF 19.6) Pub Date : 2024-02-13 Aditi Sinha, Kshetrimayum Ghanapriya Devi, Suprita Kalra, Kalaivani Mani, Pankaj Hari, Arvind Bagga
Initial therapies for children with frequently relapsing nephrotic syndrome include alternate-day prednisolone that is given daily during infections, or levamisole. In this open label, non-inferiority trial, 160 patients, 2 to 18-years-old with frequent relapses, were randomly assigned to receive either prednisolone (0.5-0.7 mg/kg/alternate-day, given daily during infections), or levamisole (2-2.5
-
Ibrutinib-associated focal segmental glomerulosclerosis and the impact of podocin mutations in chronic lymphocytic leukemia Kidney Int. (IF 19.6) Pub Date : 2024-02-08 Jan Czogalla, Simon Schliffke, Shun Lu, Maria Schwerk, Helena Petereit, Tianran Zhang, Shuya Liu, Bernhard Dumoulin, Sydney Gies, Guochao Wu, Sonja Hänzelmann, Marlies Bode, Florian Grahammer, Markus Gödel, Minna Voigtländer, Linus Butt, Carsten Bokemeyer, Carsten Bergmann, Thomas Benzing, Thorsten Wiech, Victor G. Puelles, Tobias B. Huber
[Display omitted]
-
Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity Kidney Int. (IF 19.6) Pub Date : 2024-02-05 Chaelin Kang, Donghwan Yun, Haein Yoon, Minki Hong, Juhyeon Hwang, Hyun Mu Shin, Seokwoo Park, Seongmin Cheon, Dohyun Han, Kyung Chul Moon, Hye Young Kim, Eun Young Choi, Eun-Young Lee, Myung Hee Kim, Chang Wook Jeong, Cheol Kwak, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Dong-Sup Lee, Yon Su Kim, Seung Seok Han
-
An antigen-specific chimeric autoantibody receptor (CAAR) NK cell strategy for the elimination of anti-PLA2R1 and anti-THSD7A antibody-secreting cells Kidney Int. (IF 19.6) Pub Date : 2024-02-02 Larissa Seifert, Kristoffer Riecken, Gunther Zahner, Julia Hambach, Julia Hagenstein, Gudrun Dubberke, Tobias B. Huber, Friedrich Koch-Nolte, Boris Fehse, Nicola M. Tomas
[Display omitted]
-
Single-sample measured glomerular filtration rate in Malawi, South Africa, and Uganda Kidney Int. (IF 19.6) Pub Date : 2024-02-01 Sean Currin, Jaya A. George, Christian Holm Hansen, Saraladevi Naicker, Laurie Tomlinson, Amelia Crampin, Robert Kalyesubula, Robert Newton, Wisdom P. Nakanga, Dorothea Nitsch, June Fabian
-
Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine. Kidney Int. (IF 19.6) Pub Date : 2024-01-27 Anna Reznichenko, Viji Nair, Sean Eddy, Damian Fermin, Mark Tomilo, Timothy Slidel, Wenjun Ju, Ian Henry, Shawn S. Badal, Johnna D. Wesley, John T. Liles, Sven Moosmang, Julie M. Williams, Carol Moreno Quinn, Markus Bitzer, Jeffrey B. Hodgin, Laura Barisoni, Anil Karihaloo, Matthew D. Breyer, Kevin L. Duffin, Matthias Kretzler
-
Any reduction in maternal kidney mass makes a difference during pregnancy in gestational and fetal outcome Kidney Int. (IF 19.6) Pub Date : 2024-01-29 Giorgina Barbara Piccoli, Rossella Attini, Massimo Torreggiani, Antoine Chatrenet, Ana Maria Manzione, Bianca Masturzo, Viola Casula, Elisa Longhitano, Eleonora Dalmasso, Luigi Biancone, Antonello Pani, Gianfranca Cabiddu
-
Novel mitophagy inducer alleviates lupus nephritis by reducing myeloid cell activation and autoantigen presentation Kidney Int. (IF 19.6) Pub Date : 2024-01-29 Huijing Wang, Mingdi Shen, Yanhong Ma, Lan Lan, Xue Jiang, Xufeng Cen, Gangqiang Guo, Qin Zhou, Mengmeng Yuan, Jianghua Chen, Hongguang Xia, Liang Xiao, Fei Han
-
Advancements in therapeutic development: kidney organoids and organs on a chip Kidney Int. (IF 19.6) Pub Date : 2024-01-29 Nahid Tabibzadeh, Ryuji Morizane
The use of animal models in therapeutic development has long been the standard practice. However, ethical concerns and the inherent species differences have prompted a reevaluation of the experimental approach in human disease studies. The urgent need for alternative model systems that better mimic human pathophysiology has led to the emergence of organoids, innovative models, to simulate human organs
-
Critical Role of histone deacetylase 3 in the regulation of kidney inflammation and fibrosis Kidney Int. (IF 19.6) Pub Date : 2024-01-28 Yuguo Wang, Baihai Jiao, Zhaoyong Hu, Yanlin Wang
-
Physiologic homeostasis after pig-to-human kidney xenotransplantation Kidney Int. (IF 19.6) Pub Date : 2024-01-28 Eric Judd, Vineeta Kumar, Paige M. Porrett, Kelly A. Hyndman, Douglas J. Anderson, Maggie E. Jones-Carr, Andrew Shunk, Daniel R. Epstein, Huma Fatima, Akemi Katsurada, Ryousuke Satou, L. Gabriel Navar, Jayme E. Locke