The order Herpesvirales includes animal viruses with large double-strand DNA genomes replicating in the nucleus. The main capsid protein in the best-studied family Herpesviridae contains a domain with HK97-like fold related to bacteriophage head proteins, and several virion maturation factors are also homologous between phages and herpesviruses. The origin of herpesvirus DNA replication proteins is less well understood. While analyzing the genomes of herpesviruses in the family Malacohepresviridae, we identified nearly 30 families of proteins conserved in other herpesviruses, including several phage-related domains in morphogenetic proteins. Herpesvirus DNA replication factors have complex evolutionary history: some are related to cellular proteins, but others are closer to homologs from large nucleocytoplasmic DNA viruses. Phylogenetic analyses suggest that the core replication machinery of herpesviruses may have been recruited from the same pool as in the case of other large DNA viruses of eukaryotes.

中文翻译：

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疟疾疱疹病毒蛋白的序列分析：泛疱疹病毒衣壳模块和复制酶，与“ Megavirales”有较远的联系。

疱疹病毒纲包括具有在核中复制的大双链DNA基因组的动物病毒。研究最深入的疱疹病毒科中的主要衣壳蛋白包含一个与噬菌体头部蛋白相关的HK97样折叠域，噬菌体和疱疹病毒之间也存在一些病毒体成熟因子。疱疹病毒DNA复制蛋白的起源鲜为人知。在分析疟疾家族中疱疹病毒的基因组时，我们鉴定了其他疱疹病毒中保守的近30个蛋白质家族，包括形态发生蛋白中的几个噬菌体相关结构域。疱疹病毒DNA复制因子具有复杂的进化历史：有些与细胞蛋白有关，而另一些则与大型核质DNA病毒的同源物更为接近。