Abstract Despite their excellent fouling resistance, solubility issues of zwitterionic copolymers limit their use in membrane surface modifications by coating or blending. This work presents an innovative method to form a random copolymer of polystyrene (PS) and poly(sulfobetaine methacrylate) (PSBMA), and modify in the same time poly(vinylidene fluoride) (PVDF) membranes. As the polymer is formed, it is self-deposited on the membrane. Hence, a solvent for PS-r-PSBMA does not have to be found to coat the membranes. The first part of this work consisted in optimizing the reaction conditions, by varying the SBMA to styrene monomer ratio, the reaction time and the solid content in the reactive mixture. A 50/50 monomer ratio, a reaction time of 5 h and a total solid content of 5 wt% were found to lead to a water contact angle at equilibrium close to 0 and to a reduction of 90% of fibrinogen adsorption. Using the optimized membrane, efficient resistant to fouling in complex medium was achieved, as fibrinogen from a platelet-poor-plasma solution was reduced by almost 80%, compared with the unmodified membrane. Almost complete resistance to platelets, leukocytes, erythrocytes, whole blood and E. coli adhesion were achieved. Furthermore, a flux recovery ratio (FRR) of 93% was obtained after incubating the membrane in a platelet-poor-plasma solution, outperforming a hydrophilic commercial PVDF membrane (FRR = 70%). Although further optimization of the process needs to be done, the method presented is promising for facile, stable and cost-effective surface zwitterionization of membranes.

中文翻译：

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用于减少聚偏氟乙烯膜污染的聚合和自组装组合工艺

摘要 尽管两性离子共聚物具有优异的抗污染性，但其溶解性问题限制了它们在通过涂覆或共混进行的膜表面改性中的应用。这项工作提出了一种创新方法来形成聚苯乙烯 (PS) 和聚（磺基甜菜碱甲基丙烯酸酯）（PSBMA）的无规共聚物，并同时对聚（偏二氟乙烯）（PVDF）膜进行改性。随着聚合物的形成，它会自行沉积在膜上。因此，不必发现用于 PS-r-PSBMA 的溶剂来涂覆膜。这项工作的第一部分包括优化反应条件，通过改变 SBMA 与苯乙烯单体的比例、反应时间和反应混合物中的固体含量。50/50的单体比例，发现 5 小时的反应时间和 5 重量% 的总固体含量导致平衡时的水接触角接近 0，并导致纤维蛋白原吸附减少 90%。使用优化的膜，在复杂介质中实现了有效的抗污染性，因为与未改性的膜相比，来自贫血小板血浆溶液的纤维蛋白原减少了近 80%。实现了对血小板、白细胞、红细胞、全血和大肠杆菌粘附的几乎完全抵抗。此外，在贫血小板血浆溶液中孵育膜后获得了 93% 的通量回收率 (FRR)，优于亲水性商业 PVDF 膜 (FRR = 70%)。尽管需要对过程进行进一步优化，但所提出的方法有望简化，