We read with interest the work by Haug et al published in Gut .1 Longitudinal data from 4523 participants in the first round of a faecal immunochemical test for haemoglobin (FIT)-based screening programme, of whom 3427 also participated in the second round, were studied. In both first and second rounds, a threshold of 10 µg Hb/g faeces was used. The cohort was followed up for 2 years. The cumulative positivity and the number of participants diagnosed with neoplasia over the two rounds of screening were determined and compared with a hypothetical strategy involving single round screening with use of lower faecal haemoglobin concentration (f-Hb) thresholds and omission of the second round. It was suggested that lowering the f-Hb threshold and extending the screening interval could possibly enhance population-based screening programmes. In our pilot evaluation of FIT-based screening in Scotland, a much higher f-Hb threshold (≥80 µg Hb/g faeces) was employed.2 …

中文翻译：

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是否可以通过降低阈值和增加间隔来提高基于 FIT 的定量结直肠癌筛查程序的性能？

我们饶有兴趣地阅读了 Haug 等人发表在肠道 .1 纵向数据的研究，该研究来自第一轮血红蛋白免疫化学测试 (FIT) 筛查计划的 4523 名参与者，其中 3427 人也参加了第二轮，分别是学习了。在第一轮和第二轮中，使用的阈值为 10 µg Hb/g 粪便。该队列随访了 2 年。确定了两轮筛查中的累积阳性率和被诊断为瘤形成的参与者人数，并将其与涉及使用较低粪便血红蛋白浓度 (f-Hb) 阈值和省略第二轮筛查的单轮筛查的假设策略进行比较。有人建议，降低 f-Hb 阈值和延长筛查间隔可能会加强基于人群的筛查计划。